Learn how our plate heat exchangers provide ultimate purity, precise temperature control, and zero cross-contamination protection in biologics production.
Unlike traditional chemically synthesized small-molecule drugs, the active ingredients in biologics are typically large molecules, such as proteins, nucleic acids, and polysaccharides. Biologics offer greater specificity, safety, and efficacy, and are widely used in areas such as antibody drugs, vaccines, protein drugs, and gene therapy.Biologics products include: vaccines, monoclonal antibodies, mAbs, recombinant proteins, blood products, cell and gene therapies, thrombolytics, interferon, etc. The development of biologics involves multiple fields, including molecular biology, cell engineering, fermentation engineering, and purification technologies. The production process places stringent demands on temperature, pH, sterility, and equipment cleaning. With the increasing demand for precision medicine and the accelerating aging population, biologics continue to expand their share of the global pharmaceutical market.
The production process for biologics includes fermentation, cell culture, purification, sterilization, cooling, and storage.
Cell culture and protein purification are extremely sensitive to temperature fluctuations. Precise control is essential for yield and quality.
Equipment must be easy to clean, free of dead corners, and capable of CIP/SIP (Cleaning-in-Place / Sterilization-in-Place) to meet strict sanitary standards.
In large-scale production lines, heat recovery can significantly reduce energy consumption and operating costs, promoting high efficiency and sustainability.
Heat exchange equipment in the biologics industry must comply with GMP. Heat exchangers must support cleaning-in-place and sterilization-in-place. Cross-contamination between process fluids and utility media must be prevented. Temperatures of bioreactors, fermentation broths, and culture media must be precisely controlled to the millidegree level. To protect sensitive biomolecules from damage, product materials must meet high hygienic standards and have a zero-dead-spot design.
Cell culture or microbial fermentation processes are extremely temperature-sensitive and require precise control within the optimal temperature range for growth or product synthesis. Plate heat exchangers can quickly and accurately heat or cool culture media/fermentation broth to maintain stable and suitable reaction conditions. For enzyme reactions that require specific temperatures for efficient operation, plate heat exchangers provide precise temperature control.
Get in touchBefore biologics production, culture media, buffers, or process water must be heated and sterilized (e.g., by pasteurization or ultra-high temperature sterilization). Plate heat exchangers can be used to rapidly heat and cool these fluids to achieve sterility and minimize thermal degradation. Plate heat exchangers are often used to prepare and maintain the required temperatures for cleaning solutions (CIP) or pure steam (SIP) to ensure thorough cleaning and sterilization of production equipment and pipelines, preventing contamination.
Get in touch
In downstream processes for biologics, such as chromatography, filtration, ultrafiltration, and evaporation, precise heating or cooling may be required to optimize separation efficiency and product quality. These steps also assist in separating cells or biomolecules in culture and improve the efficiency of concentration and purification.
Get in touchPlate type heat exchangers are used to cool process heat to ensure normal operating temperatures for equipment and processes. They also recover waste heat from the process to preheat incoming fluids or power other production steps, thereby reducing energy consumption and operating costs.
Get in touch
| Type | Application Features in Biopharmaceutical Industry |
|---|---|
| Gasketed Plate Heat Exchanger |
|
| Hygienic Plate Heat Exchanger |
|
| Plate Condenser |
|
| Plate Evaporator |
|
| Double Wall Plate Heat Exchanger |
|
| High Pressure Plate Heat Exchanger |
|
| Wide Gap Plate Heat Exchanger |
|
| Bloc Type / Welded PHE |
|
We understand the vital importance of biologics to patients' lives. Therefore, every one of our plate heat exchangers, from design and material selection to manufacturing, adheres to the highest standards of the US FDA, EU EMA, and global GMP. Our double-wall plate heat exchangers provide a unique physical isolation barrier. Even in the event of a plate leak, the common medium will never contaminate your process fluid, ensuring product purity and patient safety from the source. Our plate heat exchangers offer exceptional temperature control accuracy, providing an optimal growth and reaction environment for cells or microorganisms. Our plate type heat exchangers deliver efficient heat transfer while minimizing shear stress, maximizing the protection of sensitive biomolecules and cell activity.
Whether you're building a new facility or upgrading a production line, our plate exchangers fit seamlessly. Their compact modular design minimizes footprint and allows for deep customization to meet your unique process flow and space constraints.
Removable for easy maintenance and inspection. We offer hundreds of plate types, multiple materials, and multiple gasket models.
Made of food-grade materials and designed without dead angles, it is of high standard and has zero risk of contamination.
Specially manufactured for phase change processes such as steam condensation, achieves extremely high heat recovery.
Specially designed and manufactured for liquid evaporation, the special flow channel design can achieve extremely high heat transfer efficiency.
Even if leakage occurs, the medium will leak into the middle monitoring area instead of directly entering the fluid on the other side.
Aimed at energy and high-end manufacturing, it is suitable for ultra-high pressure applications such as high-pressure hydrogen production.
The unique wide flow channel design can easily handle media containing particles, fibers, pulp or high-viscosity liquids.
Without any gaskets, the risk of leakage is eliminated. It is widely used in the highest temperature, pressure and strong corrosiveness.
EN
AR
FR
DE
PT
RU
